![]() ![]() Secondary transmission was significantly less common in the breakthrough infection group than in the nonbreakthrough infection group (3 of 43 vs 29 of 110 P = .008). Results A total of 173 individuals (median age, 47 years 100 female ) with COVID-19 were included in the secondary transmission study, of whom 50 (29%) had a breakthrough infection. ![]() Main Outcomes and Measures The secondary attack rate and infectious viral shedding kinetics according to COVID-19 vaccination status. To evaluate viral shedding kinetics, the genomic RNA of SARS-CoV-2 was measured using polymerase chain reaction and performed virus culture from daily saliva samples of individuals with mild COVID-19 infected with the Delta variant who were isolated in a community facility in Seoul, South Korea, between July 20 and August 20, 2021. Objective To compare the secondary attack rate and infectious viral shedding kinetics of SARS-CoV-2 between fully vaccinated individuals (breakthrough infection group) and partially or unvaccinated individuals (nonbreakthrough infection group).ĭesign, Setting, and Participants This cohort study assessed secondary transmission by analyzing the epidemiologic data of health care workers, inpatients, and caregivers diagnosed with COVID-19 during hospitalization or residence in a tertiary care hospital between March 1, 2020, and November 6, 2021. Importance Data are limited on whether patients with breakthrough COVID-19 infection have the potential to significantly contribute to the spread of SARS-CoV-2. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment. ![]()
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